Single-use Bioreactors Market 2025-2033 Analysis: Trends, Competitor Dynamics, and Growth Opportunities

Key Insights

The size of the Single-use Bioreactors Market was valued at USD 2.1 Billion in 2024 and is projected to reach USD 5.76 Billion by 2033, with an expected CAGR of 15.5% during the forecast period. The Single-use Bioreactors Market emphasizes the utilization of disposable bioreactor systems for manufacturing biopharmaceuticals, vaccines, and various biologics. In contrast to conventional stainless-steel bioreactors, single-use bioreactors are intended for one-time application, providing notable benefits like decreased contamination risks, reduced capital and maintenance expenses, and faster setup durations. These systems are generally utilized for cell culture, fermentation, and protein production activities in biotechnology and pharmaceutical production. The market is propelled by the rising need for biologics, progress in biotechnology, and the expanding shift towards more affordable and scalable production methods. Single-use bioreactors are especially advantageous for small to medium-scale production activities and the creation of customized or unique medications. The market is further impacted by the current transition to continuous manufacturing and the increasing use of bioprocessing technologies that improve production efficiency. As the need for biologics, gene therapies, and vaccines increases, the Single-use Bioreactors Market is anticipated to see considerable growth, aiding in the optimization of biomanufacturing and enhancing the efficiency and affordability of drug manufacturing.

Single-use Bioreactors Market Concentration & Characteristics

The single-use bioreactors market is characterized by a high level of concentration among a few key players that hold a significant market share. This concentration is driven by the high capital investment and technical expertise required for the production of these specialized bioreactors. The market is also characterized by a focus on innovation and the adoption of advanced technologies, which has led to the development of novel single-use bioreactor designs and materials.

Single-use Bioreactors Market Trends

• Growing adoption in biopharmaceutical manufacturing: The rising demand for biopharmaceuticals, including monoclonal antibodies and vaccines, has fueled the adoption of single-use bioreactors in the manufacturing process.
• Accelerated research and development: Single-use bioreactors facilitate rapid prototyping and scale-up of biopharmaceutical processes, enabling faster time-to-market for new products.
• Increased focus on safety and efficiency: Stringent regulatory requirements and the need for cost-effective production methods have led to a shift towards single-use bioreactors, reducing the risk of contamination and optimizing production efficiency.

Key Region or Country & Segment to Dominate the Market

• North America: The North American region currently dominates the single-use bioreactors market, driven by the presence of major biopharmaceutical companies and a well-established healthcare infrastructure.
• Asia-Pacific: The Asia-Pacific region is expected to witness significant growth in the single-use bioreactors market due to the increasing demand for biopharmaceuticals and the presence of emerging biotech hubs.
• Stirred tank single-use bioreactors (STB): The STB segment holds the largest share of the market due to its wide applications in the production of monoclonal antibodies and other biopharmaceuticals.

Single-use Bioreactors Market Product Insights Report Coverage & Deliverables

• Comprehensive market overview and market size estimates for 2018-2032
• Analysis of key market drivers, challenges, and opportunities
• Detailed segmentation by product, cell type, molecule, usage, and end-use application
• Regional market analysis for North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa
• Market share analysis of leading players and their product portfolios
• Industry news, developments, and recent trends

Single-use Bioreactors Market Analysis

Market Size: The single-use bioreactors market is valued at USD 2.1 billion in 2022 and is projected to reach USD 12.5 billion by 2032, exhibiting a CAGR of 15.5%.

Market Share: Thermo Fisher Scientific, Sartorius Stedim Biotech Group, and Danaher Corporation are key players in the market, holding a combined market share of over 50%.

Growth Drivers: The rising demand for biopharmaceuticals, technological advancements, and increasing adoption of single-use bioreactors for efficiency and cost savings are major growth drivers for the market.

Single-use Bioreactors Market Regional Insights

• North America: U.S., Canada
• Europe: Germany, UK, France, Italy, Spain, The Netherlands, Denmark, Rest of Europe
• Asia Pacific: China, Japan, India, Australia, South Korea, Singapore, Rest of Asia Pacific
• Latin America: Brazil, Mexico, Rest of Latin America
• Middle East & Africa: South Africa, UAE, Rest of Middle East & Africa

Driving Forces: What's Propelling the Single-use Bioreactors Market

• Rising global demand for biopharmaceuticals
• Technological advancements and innovation
• Cost-effective and efficient manufacturing practices
• Stringent regulatory requirements for safety and quality

Challenges and Restraints in Single-use Bioreactors Market

• High capital investment and production costs
• Supply chain disruptions
• Regulatory hurdles in some regions
• Availability of trained workforce

Emerging Trends in Single-use Bioreactors Market

• Bioreactor design optimization for increased efficiency
• Integration of automation and control systems
• Advanced materials and technologies for improved performance
• Single-use bioreactors for cell and gene therapies

Single-use Bioreactors Industry News

• December 2022: Merck KGaA acquired Erbi Biosystems, strengthening its portfolio of single-use bioreactors.
• March 2021: Thermo Scientific launched the HyPerforma DynaDrive single use bioreactors 3,000 L and 5,000 L models for large-scale bioprocesses.

Leading Players in the Single-use Bioreactors Market

• Thermo Fisher Scientific
• Solaris Biotech Solutions
• Shanghai Bailun Biotechnology Co. Ltd.
• Sartorius Stedim Biotech Group
• Pierre Guerin Sas (Engie)
• PBS Biotech
• Danaher Corporation
• Merck Group
• GEA Group Aktiengesellschaft
• Eppendorf AG
• CESCO Bioengineering Co. Ltd.
• CerCell ApS
• Cellexus Ltd
• Bbi Biotech
• Applikon Biotechnology, Inc. (Getinge)

Single-use Bioreactors Market Segmentation

• 1. The market by product is categorized into stirred tank single-use bioreactors, wave-mixed single-use bioreactors, bubble column single-use bioreactors, and others. The stirred tank single-use bioreactors segment garnered USD 1.5 billion revenue size in the year 2022.
  • 1.1. Single-use bioreactors eliminate the need for cleaning and sterilization between batches, significantly reducing the risk of cross-contamination between different products or batches. This is crucial in the production of biopharmaceuticals, where even trace amounts of contaminants can compromise the entire batch.
  • 1.2. Moreover, traditional stainless-steel bioreactors require significant capital investment and operating costs for cleaning, sterilization, and maintenance. Single-use bioreactors eliminate these costs associated with cleaning and validation, leading to overall cost savings.
• 2. The single-use bioreactors market by end-use is categorized into R&D organizations, biopharma manufacturers, contract manufacturing organizations. Biopharma manufacturers held 45% of industry share in 2022.
  • 2.1. Increase in number of biopharmaceutical products in pipeline including antibodies and antibody drug conjugates coupled with rising number of new facilities to meet the production needs is anticipated to augment segment landscape.
  • 2.2. Growing adoption of advanced technologies to ease complex manufacturing will stimulate industry demand in upcoming years.
  • 2.3. Moreover, single-use bioreactors cater wide applications in development and manufacturing of complex molecules such as proteins and nucleic acids is estimated to drive the segment size.
• 3. Product, 2018-2032 (USD Million)
  • 3.1. Stirred tank single-use bioreactors
  • 3.2. Wave-mixed single-use bioreactors
  • 3.3. Bubble column single-use bioreactors
  • 3.4. Other products
• 4. Cell, 2018-2032 (USD Million)
  • 4.1. Mammalian cells
  • 4.2. Bacterial cells
  • 4.3. Yeast cells
  • 4.4. Other cells
• 5. Molecule, 2018-2032 (USD Million)
  • 5.1. Monoclonal antibodies
  • 5.2. Vaccines
  • 5.3. Recombinant proteins
  • 5.4. Stem cells
  • 5.5. Gene therapy
  • 5.6. Other molecules
• 6. Usage, 2018-2032 (USD Million)
  • 6.1. Developmental, pre-clinical & clinical
  • 6.2. Commercial production
• 7. End-use, 2018-2032 (USD Million)
  • 7.1. R&D organizations
  • 7.2. Biopharma manufacturers
  • 7.3. Contract manufacturing organizations

Single-use Bioreactors Market Segmentation By Geography

• 1. North America
  • 1.1. U.S.
  • 1.2. Canada
• 2. Europe
  • 2.1. Germany
  • 2.2. UK
  • 2.3. France
  • 2.4. Italy
  • 2.5. Spain
  • 2.6. The Netherlands
  • 2.7. Denmark
  • 2.8. Rest of Europe
• 3. Asia Pacific
  • 3.1. China
  • 3.2. Japan
  • 3.3. India
  • 3.4. Australia
  • 3.5. South Korea
  • 3.6. Singapore
  • 3.7. Rest of Asia Pacific
• 4. Latin America
  • 4.1. Brazil
  • 4.2. Mexico
  • 4.3. Rest of Latin America
• 5. Middle East & Africa
  • 5.1. South Africa
  • 5.2. UAE
  • 5.3. Rest of Middle East & Africa